Experience with immunotherapy in 3 patients with cerebellar ataxia associated with anti-glutamic acid decarboxylase antibodies.
نویسندگان
چکیده
La asociación con niveles altos de anticuerpos contra la enzima carboxilasa del ácido glutámico (anti-GAD) es bien conocida en el síndrome de la persona rígida o Stiff person syndrome (SPS) y, más recientemente, también se han descrito en un subgrupo de pacientes con ataxia cerebelosa1,2. Sobre la base del probable origen autoinmune de estos síndromes se han ensayado distintas terapias inmunomoduladoras con resultados variables3—5, pero no hay estudios que describan cuál es la evolución a largo plazo de estos pacientes. Se describen la respuesta clínica inicial y la evolución a largo plazo con terapia inmunomoduladora en 2 pacientes con ataxia cerebelosa con anticuerpos anti-GAD. Se presenta un tercer caso con SPS y ataxia cerebelosa asociada de larga evolución y se describe la diferente respuesta al tratamiento entre ambas manifestaciones clínicas.
منابع مشابه
P102: The Association of the Anti-GAD Antibodies to the Neurological Conditions
Glutamic acid decarboxylase (GAD) is an enzyme which converts the glutamic acid to the neurotransmitter gamma-amino butyric acid (GABA). GABA is an inhibitory neurotransmitter that inhibits or weakens the neuronal stimulations. Presynaptic GABAergic neurons in the central neurons system (CNS) and the cells in the islets of Langerhans in the pancreas generate GAD. There are two isoforms of GAD n...
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ورودعنوان ژورنال:
- Neurologia
دوره 30 4 شماره
صفحات -
تاریخ انتشار 2015